Molecular BiologyLife Science AlliancePeer-reviewed
Main constraints for RNAi induced by expressed long dsRNA in mouse cells
Tomáš Demeter, Michaela Vaškovičová, Radek Malı́k…·Petr Svoboda
The paper identifies siRNA production as the main constraint for RNAi in mouse cells, showing that Dicer activity, dsRNA structure, and targeting efficiency are critical factors.