Michaela Vaškovičová

This paper describes a method to co-isolate AAV with extracellular vesicles for efficient genome editing in rodent embryos, achieving higher viability and targeting efficiency compared to traditional purification methods.

This study shows TEAD4 maintains trophectoderm lineage integrity by regulating apical domain morphology and cell positioning in mouse preimplantation embryos.

This study identifies the spatio-temporal roles of AURKA in mouse oocyte meiotic spindle formation using genetic and imaging approaches.

This study identifies CHK1's role in regulating cell cycle progression in early mouse embryos to maintain genome integrity and prevent aneuploidy.

The paper identifies siRNA production as the main constraint for RNAi in mouse cells, showing that Dicer activity, dsRNA structure, and targeting efficiency are critical factors.