Wynn Legon

Acoustic Coupling for Double-Blind Human Low-Intensity Focused Ultrasound Neuromodulation

This paper develops a double-blind coupling device for low-intensity focused ultrasound neuromodulation, demonstrating acoustic transparency and energy control.

Focal brain stimulation sites that modify autonomic arousal map to a convergent brain circuit and potential therapeutic target

The paper identifies a convergent brain circuit modulated by neuromodulation techniques that reduces autonomic arousal in various conditions.

Wearable Focused Ultrasound Neuromodulation and Electrophysiological Recording Patch for REM Sleep Enhancement

This paper introduces a wearable patch for non-invasive ultrasound neuromodulation and sleep recording, showing increased REM sleep duration and reduced latency in human subjects.

Focused Ultrasound modulates dopamine in a mesolimbic reward circuit

This study shows that low-intensity focused ultrasound at 13 W/cm2 reduces dopamine release in the nucleus accumbens core by ~50% for up to 2 hours without causing tissue damage.

Examination of low-intensity focused ultrasound parameters for human neuromodulation

This study examines how different parameters of low-intensity focused ultrasound affect human brain activity, finding inhibition in some cases and no excitation.

Low-intensity focused ultrasound to the human insular cortex differentially modulates the heartbeat-evoked potential: a proof-of-concept study

This study uses LIFU to target brain regions involved in the HEP and finds that PI modulation decreases HEP amplitudes.

Low-intensity focused ultrasound to the insula and dorsal anterior cingulate has site-specific and pressure dependent effects on pain during measures of central sensitization

This study investigates the effects of low-intensity focused ultrasound on pain measures in specific brain regions and finds that posterior insula and dorsal anterior cingulate cortex modulation reduces pain differently.

Non-invasive modulation of the human dorsal anterior cingulate attenuates acute pain perception and homeostatic cardiovascular responses

This study uses low-intensity focused ultrasound to non-invasively modulate the dorsal anterior cingulate cortex, reducing pain perception and altering cardiovascular responses to heat pain.

Non-invasive neuromodulation of sub-regions of the human insula differentially affect pain processing and heart-rate variability

This study uses low-intensity focused ultrasound to non-invasively target specific sub-regions of the human insula, showing differential effects on pain perception and heart-rate variability.

Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI

This study examines the effects of transcranial focused ultrasound on human motor cortex using 7T fMRI, finding increased activation volume in targeted finger representations without effects on connected regions.

Transcranial focused ultrasound neuromodulation of the human primary motor cortex

This study investigates the effects of transcranial focused ultrasound on human motor cortical excitability and behavior, finding inhibition of motor evoked potentials and reduced reaction times.

Ultrasound Produces Extensive Brain Activation via a Cochlear Pathway

This study shows ultrasound activates brain regions via a cochlear pathway, not directly, by vibrating cerebrospinal fluid connected to the cochlea.

Safety of transcranial focused ultrasound for human neuromodulation

This study evaluates the safety of transcranial focused ultrasound (tFUS) for human neuromodulation, finding no serious adverse effects and minor transient symptoms reported.