David Bryder

Transcriptional Roadmap of the Human Airway Epithelium Identifying HLF as a Novel Regulator of Basal Stem Cell Function

The paper maps the transcriptional landscape of the human airway epithelium and identifies HLF as a regulator of basal stem cell function and tumor suppression.

NK cells control the progression of myelodysplastic syndrome but become initial disease target in NUP98-HOXD13 mouse model

The paper shows NK cells control MDS progression but are dysregulated in NUP98-HOXD13 mice, with genetic markers shared between mice and human MDS/AML.

Nabo - a framework to define leukemia-initiating cells and differentiation in single-cell RNA-sequencing data

Nabo maps cells from one population to the most similar cells in a reference population, improving accuracy in identifying tumor-initiating cells in single-cell RNA-Seq data.

HSCs contribute actively to native multilineage hematopoiesis but with reduced differentiation capacity upon aging

This study shows that adult HSCs contribute to all blood lineages in steady state but decline in contribution with age due to reduced differentiation capacity.