Zaal Kokaia

This study uses longitudinal tractography to track thalamocortical degeneration after cortical stroke and shows that hiPSC-derived neuronal transplantation preserves thalamic connectivity and reduces atrophy.

This study develops a method to efficiently generate human oligodendrocytes from induced pluripotent stem cells, which can form functional myelinating grafts in adult human brain tissue.

The paper examines how age and sex influence gene expression in human monocyte subtypes related to neuroinflammation and regeneration, identifying age- and sex-dependent gene changes.

The paper shows that DNA methylation and the HUSH-MORC2 complex independently regulate repeat elements in human neural progenitor cells, with MORC2 binding increasing in demethylated regions.

This study generates human cortical neurons from hES cells via NGN2 overexpression and shows their integration into stroke-injured rat brains.

This study shows L1 retrotransposons contribute to human brain transcriptome complexity and functional diversification through cell-type specific transcripts and regulatory RNAs.

This study shows human iPS cell-derived oligodendrocytes can remyelinate adult rat and human cortical neurons in vitro and in vivo.

The paper investigates fibrotic scarring in CNS lesions across species and lesion types, finding pericyte-derived fibrosis as a conserved mechanism.

This study shows HIF-2α regulates neural crest stemness and development, with implications for neuroblastoma.

This study shows that adult HSCs contribute to all blood lineages in steady state but decline in contribution with age due to reduced differentiation capacity.