Göran Karlsson

The paper shows fetal hematopoietic stem and progenitor cells (HSPCs) have greater lineage plasticity than adult HSPCs, linked to chromatin accessibility differences.

CyteType improves cell type annotation in single-cell transcriptomics by combining multi-agent reasoning with external validation, achieving higher accuracy than existing methods.

The paper presents a single-cell map of first trimester human fetal liver hematopoiesis, identifying molecular and immunophenotypic differences from adult cells and linking findings to pediatric leukemia.

Scarf provides a memory-efficient toolkit for analyzing large-scale single-cell genomics data on standard hardware.

A genome-wide association study identifies DNA variants influencing HSPC levels in human blood, with PPM1H as a novel regulator affecting stem cell subpopulations.

This study shows that adult HSCs contribute to all blood lineages in steady state but decline in contribution with age due to reduced differentiation capacity.