The role of Platelet-derived growth factor (PDGF) in uremic vascular calcification.
Burcu Yesilyurt Öztürk, Li Zhang, Saskia Freifrau von Stillfried, Barbara M. Klinkhammer, Julia Möllmann, Patrick Droste, Eva Miriam Buhl, Mathias Hohl, Heidi Noels, Vera Jankowski, Joachim Jankowski, Claudia Goettsch, Nikolaus Marx, Lorin E. Olson, Jürgen Floege, , Peter Boor
This study investigates the role of PDGFR-{beta} in uremic vascular calcification using ex vivo and in vivo models, showing that PDGFR-{beta} activation promotes calcification and VSMC phenotypic switching.
bioRxiv · Jul 9, 2025 · PreprintSystems Biology