Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex
Yuka Mitsuhashi Koike, Akihiro Sugai, Norikazu Hara, Junko Itô, Akio Yokoseki, Tomohiko Ishihara, Takuma Yamagishi, Shintaro Tsuboguchi, Mari Tada, Takeshi Ikeuchi, Akiyoshi Kakita, Osamu Onodera
The paper shows that age-related DNA demethylation in the TARDBP 3'UTR reduces alternative splicing and increases TARDBP mRNA expression in the human motor cortex, linking this to earlier ALS onset.
Communications Biology · Sep 21, 2021Peer-reviewedMolecular Biology