Mari Tada

This study identifies a role for subarachnoid macrophages in amyloid-beta clearance and vascular dysfunction in Alzheimer's disease using mouse models and intravital imaging.

The paper identifies APOE rare missense variants in the Japanese population and finds two variants associated with protective effects against Alzheimer's disease.

The paper shows that age-related DNA demethylation in the TARDBP 3'UTR reduces alternative splicing and increases TARDBP mRNA expression in the human motor cortex, linking this to earlier ALS onset.