GeneticsJournal of Clinical InvestigationPeer-reviewed
MANF Clears Mutant Uromodulin in Human Kidney Organoids of Autosomal Dominant Tubulointerstitial Kidney Disease
Chenjian Gu, Yili Fang, Y. M. Wang…·Ying Maggie Chen
This study shows MANF reduces mutant uromodulin in kidney organoids by enhancing autophagy through IP3R1 repression, suggesting potential for treating ADTKD and similar protein misfolding diseases.
DOI 10.1172/jci205631