Christopher C. Kyriazis

The paper investigates hatching failure in Alala, the Hawaiian crow, after a near-extinction event, identifying recessive lethal haplotypes as the main cause.

The paper reconstructs the demographic history of Rice's whale using whole-genome sequences and assesses its genomic health, finding long-term isolation and a recent population collapse increase extinction risk.

The paper extends the stdpopsim simulation framework to include realistic selection models, enabling studies of selection's impact on genetic variation across species.

This study examines the distribution of fitness effects (DFE) across eleven animal species, finding that DFE co-varies with phylogeny and that mammals have more deleterious mutations than insects and birds.

This paper estimates dominance and selection parameters for nonsynonymous mutations in humans using site frequency spectra and explores their implications for genetic load and inbreeding depression.