Author

Shintaro Shichinohe

The University of OsakaORCID 0000-0002-8783-2103Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Ayato TakadaiD· 1 shared Daiki KobayashiiD· 1 shared Daisuke MotookaiD· 1 shared Eiryo KawakamiiD· 1 shared Hikaru SugimotoiD· 1 shared Kazuo TakayamaiD· 1 shared Mai thi Quynh Le· 1 shared Makoto Shimooka· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMicrobiology

Ayato TakadaORCID

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1 paper

Recent·Most cited

A cattle-derived human H5N1 isolate suppresses innate immunity despite efficient replication in human respiratory organoids

Shintaro Shichinohe, Hikaru Sugimoto, Masako Yamasaki, Rina Hashimoto, Tatsuru Morita, Daiki Kobayashi, Takahiro Hiono, Daisuke Motooka, Makoto Shimooka, Norikazu Isoda, Mai thi Quynh Le, Ayato Takada, Yoshihiro Sakoda, Eiryo Kawakami, Kazuo Takayama, Tokiko Watanabe

This study uses human respiratory organoids to show that a cattle-derived H5N1 isolate replicates efficiently but suppresses innate immune responses, explaining its mild clinical presentation in humans.

bioRxiv · Nov 2, 2025 · PreprintMicrobiology