Hikaru Sugimoto

A thermoregulatory design principle for transitions into hypometabolism

The paper identifies dynamical signatures and a mathematical principle underlying the transition from normothermia to hypothermia in mammals.

A single-nucleus and spatial transcriptomic atlas of the Syrian hamster preoptic area across hibernation states

This study creates a transcriptomic atlas of the Syrian hamster preoptic area using snRNA-seq and spatial transcriptomics, comparing seasonal and hibernation states.

A cattle-derived human H5N1 isolate suppresses innate immunity despite efficient replication in human respiratory organoids

This study uses human respiratory organoids to show that a cattle-derived H5N1 isolate replicates efficiently but suppresses innate immune responses, explaining its mild clinical presentation in humans.

Uncertainty-aware transcription factor activity and perturbation inference without additional training

TFActProfiler improves TF activity inference and perturbation prediction using pre-trained TF-mRNA interactions and RNA-seq data without additional training.

Metabolic Trans-Omic Analysis Reveals Key Regulatory Disruption of Energy Metabolism in Alzheimer's Disease

The paper integrates multi-omic data from Alzheimer's disease patients to reveal coordinated downregulation of energy-producing metabolic pathways.

Global loss of responsiveness in key regulator metabolites and elevated enzyme proteins as metabolic dysregulation in skeletal muscle and liver of obese mice during starvation

The paper examines metabolic adaptations during starvation in obese mice, finding impaired responsiveness and elevated enzyme expression in skeletal muscle and liver.

Structural robustness and temporal vulnerability of the starvation-responsive metabolic network in liver of healthy and obese mice

The paper examines how obesity disrupts the temporally ordered metabolic network in the liver during starvation, revealing structural robustness but temporal vulnerability.

iTraNet: A Web-Based Platform for integrated Trans-Omics Network Visualization and Analysis

iTraNet is a web tool for visualizing and analyzing trans-omics networks, revealing differences in hub molecule responses to glucose between wild-type and ob/ob mice.

DI/cle, a Measure Consisting of Insulin Sensitivity, Secretion, and Clearance, Captures Diabetic States

The paper introduces DI/cle, a new index combining insulin sensitivity, secretion, and clearance, showing it is impaired in T2DM but not in IGT.