Christian Grimm

This study investigates how chronic hypoxia reprograms metabolism and alters redox and lipid homeostasis in rod photoreceptors using a mouse model.

The paper examines energy metabolism in retinal neurons, showing photoreceptors use both aerobic glycolysis and OXPHOS while inner retinal neurons rely on OXPHOS, and identifies metabolic changes in a retinitis pigmentosa mutation.

This paper develops a dual-acting RNAi therapy targeting Hif1a and Hif2a to protect retinal cells in AMD models, showing superior efficacy compared to single-target therapies.

This study investigates the effects of a histone demethylase inhibitor on cone cell survival in a mouse model of cone dystrophy, finding epigenetic modulation improves cone survival.

The paper examines circadian regulation of visual transduction regulators in zebrafish and mice, finding rhythmic gene expression and physiological responses aligned with their diurnal/nocturnal activity patterns.

This study shows HDAC inhibition delays cone death in RP mice by protecting multiple survival pathways, even after most rods have degenerated.