Assessment of pharmacokinetics, safety, and neuroprotective efficacy of an adjunct intramuscular verapamil therapy in a rat model of organophosphate DFP-induced status epilepticus
Yam Nath Paudel, Robert E. Blair, Elisa Hawkins, Matthew S. Halquist, Melissa Morgan, Jason Funderburk, Daniel Calvano, Jennifer E. Koblinski, Hope Richard, Laxmikant S. Deshpande
This study evaluates the safety, pharmacokinetics, and neuroprotective effects of intramuscular verapamil in a rat model of organophosphate-induced status epilepticus, showing improved brain levels and neuroprotection compared to oral administration.
bioRxiv · Jun 25, 2025 · PreprintPharmacology & Toxicology