Emma L. Rawlins

This study shows hypoxia promotes airway differentiation in human lung epithelial progenitors through HIF pathways, with implications for lung disease.

This study shows mTOR dysregulation in LAM causes IL6 production and senescence in AT2 cells, impairing lung repair, and suggests targeting IL6 may help.

The paper constructs a human fetal lung cell atlas from 5-22 post conception weeks, identifying new cell states and regulators of epithelial fates.

The paper uses a CRISPRi screen in human fetal lung organoids to identify SOX9 as a key regulator of progenitor self-renewal, showing it primes cells to receive WNT and RTK signals.

This paper develops a genetic toolbox for tissue-derived human organoids, enabling efficient gene manipulation through CRISPR-based methods and flow cytometry.

This study identifies a human fetal lung progenitor cell population with alveolar fate potential and develops an organoid system to study alveolar development mechanisms.