Qianxin Wu

SELECT-seq allows Pre-Sequencing Enrichment of SNP Edits in One-Pot Single-Cell Whole-Transcriptome Sequencing

SELECT-seq enables rapid, scalable SNP-specific enrichment of single cells for genotype-phenotype analysis without cloning.

Prevention of Transgene Silencing During Human PluripotentStem Cell Differentiation

The paper identifies strategies to prevent transgene silencing during human pluripotent stem cell differentiation and introduces a robust vector construct.

High-throughput phenotyping of single nucleotide variants by linking transcriptomes to genotypes in single cells

This study links single-cell transcriptomes to genotypes to assess the functional impact of single nucleotide variants, classifying missense variants into three categories.

Screening for functional regulatory variants in open chromatin using GenIE-ATAC

The paper introduces GenIE-ATAC, a medium-throughput method to screen regulatory variants' effects on chromatin accessibility, validating causal variants and extending analysis tools.

Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells

The paper analyzes genomic variation in hiPSCs derived from skin and blood, finding high mutation rates in fibroblast-derived lines and frequent BCOR mutations in blood-derived lines.

INSIGHT: a population scale COVID-19 testing strategy combining point-of-care diagnosis with centralised high-throughput sequencing

The paper introduces a two-stage COVID-19 testing strategy combining point-of-care diagnosis with centralised high-throughput sequencing to enable population-scale testing.