Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons
Claire Gao, Isabelle C. Geneve, Shakira Rodriguez-Gonzalez…·Michael J. Krashes
This study identifies that semaglutide induces weight loss via cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons through both Gs- and Gq-signaling pathways.