Michael J. Krashes

This study identifies POA H1 receptor-expressing neurons as key regulators of thermoregulatory behaviors, including body temperature rhythms and nest building.

This study identifies that semaglutide induces weight loss via cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons through both Gs- and Gq-signaling pathways.

This study shows that requiring mice to perform a simple action to access high-fat diet reduces intake and prevents obesity, suggesting that easy access promotes overeating.

The paper identifies a neural circuit involving TrhArc neurons that mediate the appetite-suppressing effects of GLP-1RAs by inhibiting AgRP neurons.

This study identifies a hypothalamic circuit involving ARCAgRP and MPOABRS3 neurons that modulates the prioritization of feeding and parenting behaviors during lactation.

This study identifies AgRP neuron activity as a key factor in activity-based anorexia and shows that activating these neurons can mitigate the condition.

The paper identifies two subpopulations of parasubthalamic nucleus neurons in mice and shows that PSTNTac1 neurons are essential for appetite suppression.

The paper identifies POA BRS3 neurons that increase body temperature and heart rate through multiple pathways, revealing their role in thermoregulation and cardiovascular control.

This study shows that locus coeruleus-norepinephrine (LC-NE) neurons modulate feeding by integrating external and internal cues, with their activity changing during food approach and consumption.