Author

Haoxiang Li

Center for Life SciencesORCID 0000-0002-8838-8227Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:contrastive learning· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:graph neural network· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Jiqing ZhengiD· 2 shared Bin LiiD· 1 shared Guiyu Guan· 1 shared Hao Zhang· 1 shared Huasong AiiD· 1 shared Jiawei LiangiD· 1 shared Lei LiuiD· 1 shared Lei LiuiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Jiqing ZhengORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJun 19, 2025

MFPLI: A Computational Framework for Assessing Biological Authenticity of Protein-Ligand Interactions Using Molecular Fingerprints and Structural Features

Hao Zhang, Jiqing Zheng, Haoxiang Li…·Wei He

MFPLI evaluates protein-ligand binding authenticity using deep learning with physicochemical and structural features, achieving high accuracy in distinguishing native conformations from docking poses.

DOI 10.1101/2025.06.19.659858

protein structuredeep learning

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BiochemistrybioRxivPreprintJun 8, 2025

A Cryptic Interfacial Pocket Uncovered in Full CRL4CRBN-IKZF3 Ubiquitylation Complex Enhances IMiD Efficacy

Zhiheng Deng, Huasong Ai, Qiang Shi…·Lei Liu

The paper determines cryo-EM structures of IMiDs in full CRL4CRBN complexes, revealing a cryptic interfacial pocket that enhances IMiD efficacy and neosubstrate specificity.

2 citations

cryo-EMexperimental assay

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