Venkatesh Endalur Gopinarayanan

This paper introduces a metabolic coordinator, Gal3pMC, that enables efficient activation of the GAL regulon across diverse substrates, improving growth rates and substrate utilization in yeast.

This study shows that yeast can adapt rapidly to non-native substrates with minimal metabolic engineering by integrating non-native genes with a native regulon system.

The paper develops a computational method to identify enzyme promiscuity-induced metabolic network disruptions in engineered microbial hosts and evaluates its application in two case studies.

This paper introduces ProPASS, a workflow that links pathway synthesis with enzyme-host compatibility using solubility scores, and presents ProSol DB, a database of solubility scores for 240,016 enzymes in E. coli.