Author

Tyler Ralph-Epps

Wayne State UniversityORCID 0000-0002-3001-8581Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:experimental assay· 2 Assay:metabolomics· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

Miriam L. GreenbergiD· 2 shared Abu Mohammed RamimiD· 1 shared Hyejeong JangiD· 1 shared Janaka S. S. LiyanageiD· 1 shared Kaitlin LowraniD· 1 shared Linh VoiD· 1 shared Mária Balážová· 1 shared Michael SchlameiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

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10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Miriam L. GreenbergORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJul 20, 2026

✦ In-depth digest

Loss of TAFAZZIN leads to perturbation of amino acid metabolism and reduction of collagen synthesis

Abu Mohammed Ramim, Tyler Ralph-Epps, Linh Vo…·Miriam L. Greenberg

TAFAZZIN-knockout C2C12 myoblasts show elevated proline catabolism into the TCA cycle alongside reduced collagen content, proline hydroxylation, crosslinking enzyme LOX, and proline incorporation into ECM proteins.

1 citation

mousemetabolomics

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Cell BiologybioRxivPreprintFeb 3, 2024

Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction and leads to increased glucose uptake in tafazzin-deficient cells

Zhuqing Liang, Tyler Ralph-Epps, Michael W. Schmidtke…·Miriam L. Greenberg

This study identifies the upregulation of the AMPK-FOXO1-PDK4 pathway as the mechanism causing reduced PDH activity and increased glucose uptake in tafazzin-deficient cells.

DOI 10.1101/2024.02.03.578755

mousemetabolomics

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