Author

Paul C. Lorigan

University of ManchesterORCID 0000-0002-8875-2164Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Alexandrine CarminatiiD· 1 shared Anandita Mathur· 1 shared Avinash GuptaiD· 1 shared Brian Ritchie DavidsoniD· 1 shared Charlotte ButtercaseiD· 1 shared Erik A. SahaiiD· 1 shared Gareth J. PriceiD· 1 shared Ginevra Pistocchi· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Alexandrine CarminatiORCID

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1 paper

Recent·Most cited

ImmunologybioRxivPreprintSep 30, 2025

Splenic granulopoiesis and S100A9 drive resistance to checkpoint inhibitors conferred by liver metastases

Rebecca J. Lee, Steven Hooper, Laura J. Pallett…·Erik A. Sahai

This study shows liver metastases reduce checkpoint inhibitor efficacy by increasing splenic granulopoiesis and S100A9hi neutrophils, which suppress T-cell responses, and demonstrates that targeting S100A9 restores efficacy.

DOI 10.1101/2025.09.30.679035

mousebulk RNA-seq