Steven Hooper

This study shows that cooperative and antagonistic interactions between sub-clones in melanoma allow multiple resistance mechanisms to coexist, and identifies GSK-J4 as a potential therapeutic target.

The paper identifies neuronal mimicry in cancer-associated fibroblasts driven by calcium waves, leading to immune exclusion, and shows that blocking this process restores immune control.

This study shows that radiation-induced podoplanin-positive fibroblasts limit CD8+ T-cell access to tumour cells, reducing radiotherapy effectiveness, and that disrupting PDPN signaling enhances tumour control.

This study shows liver metastases reduce checkpoint inhibitor efficacy by increasing splenic granulopoiesis and S100A9hi neutrophils, which suppress T-cell responses, and demonstrates that targeting S100A9 restores efficacy.

This study shows that cell migration and stromal fibroblasts influence subclone competition in lung cancer, promoting therapy resistance through increased cell mixing.

The paper uses single-cell imaging to show that drug-tolerant cells in EGFR-mutant lung cancer rewired ERK signaling through endocytic pathways and adhesion complexes, driven by YAP and PTPRS.

This study identifies mechanisms regulating YAP1 nuclear shuttling in fibroblasts, showing that Src and actomyosin suppress YAP1 export, and nuclear export is central to YAP1 regulation.