Author

Timothy Paul Hickling

Pfizer (United States)ORCID 0000-0002-8918-2140Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Approach:benchmark study· 1 Assay:clinical cohort / trial· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Sophie TourdotiD· 3 shared Andrew Ciarla· 2 shared Benjamin Keenan· 2 shared Jennifer Calderini· 2 shared Rachel Hindin· 2 shared Brinda Monian· 1 shared Bruno Gonzalez-NolascoiD· 1 shared Chloé Ackaert· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersPharmacology & Toxicology

Sophie TourdotORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The Immunogenicity Database Collaborative (IDC): A Standardized, Publicly Available Database for Clinical Immunogenicity Observations and Insights

Sudhanshu Agnihotri, Bruno Gonzalez-Nolasco, Brinda Monian, Sofie Pattijn, Chloé Ackaert, Patrick Wu, Hubert Kettenberger, Sophie Tourdot, Timothy Paul Hickling, Zicheng Hu, Richard E. Higgs, Daniel S. Leventhal

The paper introduces the Immunogenicity Database (IDC) to standardize and integrate clinical immunogenicity data, highlighting trends in anti-drug antibody incidence and risk factors.

Frontiers in Immunology · Jun 30, 2026Peer-reviewedPharmacology & Toxicology

Statistical Methodology for Qualification of a Non-Clinical Risk Assessment Peptide:T Cell Proliferation Assay to Support Decision Making

Sophie Tourdot, Zhiping You, Andrew Ciarla, Rachel Hindin, Benjamin Keenan, Jennifer Calderini, Shea Van den Broek, Christopher S. Lepsy, Timothy Paul Hickling, Gregory S. Steeno

The paper develops a statistical framework to validate a T cell proliferation assay for immunogenicity risk assessment in biologics development.

bioRxiv · Jun 8, 2026 · PreprintImmunology

HLAIIPred: Cross-Attention Mechanism for Modeling the Interaction of HLA Class II Molecules with Peptides

Mojtaba Haghighatlari, Nicholas A. Marze, Robert Seward, Andrew Ciarla, Rachel Hindin, Jennifer Calderini, Benjamin Keenan, Santosh S. Dhule, Sarah Hall-Swan, Timothy Paul Hickling, Eric M. Bennett, K. Brajesh, Sophie Tourdot

HLAIIPred predicts HLAII-presented peptides using a Transformer-based model, outperforming existing methods and identifying core interaction residues.

Communications Biology · Jul 30, 2025Peer-reviewedBioinformatics