Chuan Jiao

The paper identifies that canonical CENP-B boxes are highly conserved in centromeres but not in ectopic sites, showing selective conservation and functional binding.

The paper identifies molecular signatures of neuronal hyperexcitability and lithium responsiveness in bipolar disorder neurons, suggesting new therapeutic strategies targeting Akt and AMPK pathways.

The paper constructs a cross-ancestry, cell-type-informed gene regulatory atlas of the developing human brain, identifying genetic regulation and linking it to neuropsychiatric disorders.

The paper identifies correlated DNA methylation and gene expression pairs across tissues and brain development stages, finding most are tissue-specific and revealing novel regulatory mechanisms.

The paper compiles and analyzes transcriptomic data from six neuropsychiatric disorders, identifying differentially expressed genes and co-expression networks across brain regions.

The paper evaluates brain cell marker genes using differential and co-expression data, identifying 22 gold standard and 16 novel candidates with improved specificity.

The paper identifies positional effects in Illumina Methylation Arrays and shows how they impact methylation measurements, recommending ComBat for correction.