Yu Chen

xQTLbiolinks is a tool for integrative analysis of molecular QTLs, enabling retrieval, preprocessing, and colocalization with GWAS data to identify disease-risk genes.

The paper investigates the impact of the NLGN3 R451C mutation on human neurons, finding it reduces protein levels but enhances excitatory synapses, potentially contributing to ASD pathogenesis.

The paper identifies DNA base-excision repair as a mechanism that amplifies transcriptional noise, enhancing cellular plasticity and reprogramming efficiency.

This study identifies fever and infection as major agonal factors affecting gene expression in postmortem brains and recommends correcting for these factors using PEER or SVA.

The paper evaluates brain cell marker genes using differential and co-expression data, identifying 22 gold standard and 16 novel candidates with improved specificity.