RegulomeXplorer analyzes subcellular proteomics data to visualize drug effects on protein abundance across compartments and generate mode of action hypotheses.

bioRxiv · Jul 3, 2026 · PreprintBioinformatics

Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis.

Zuzana Outla, Gizem Oyman-Eyrilmez, Katerina Korelova, Magdalena Přechová, Lukas D. Frick, Lenka Sarnová, Piyush Bisht, Petra Novotná, Jan Kosla, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Mohammad Rahbari, Nuh N. Rahbari, , Martin Gregor

This study identifies plectin as a critical mediator of mechanical homeostasis in hepatocellular carcinoma, showing that its inhibition suppresses tumor growth and metastasis.

eLife · Mar 7, 2025Peer-reviewedCancer Biology

Multi-Omics Data of Perturbation Studies are Determined by Memory Effects from Subculture

Patricia Bortel, Gerhard Hagn, Lukas Skos, Andrea Bileck, Verena Paulitschke, Philipp Paulitschke, Lion Gleiter, Thomas T. Mohr, Christopher Gerner, Samuel M. Meier

The paper shows that subculture memory effects increase variation in omics data from perturbation studies, improving deconvolution and revealing causal networks.

bioRxiv · Feb 13, 2023 · PreprintSystems Biology

Caffeine-induced Plasticity of Grey Matter Volume in Healthy Brains: A placebo-controlled multimodal within-subject study

Yu-Shiuan Lin, Janine Weibel, Hans‐Peter Landolt, Francesco Santini, Martin Meyer, Julia Brunmair, Samuel M. Meier, Christopher Gerner, Stefan Borgwardt, Christian Cajochen, Carolin Reichert

This study shows that daily caffeine intake reduces grey matter volume in humans and impairs working memory, suggesting potential long-term cognitive detriments.

Cerebral Cortex · Jan 6, 2021Peer-reviewedNeuroscience