Author

Rui Zhong

University of MinnesotaORCID 0000-0002-8936-6652Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Rui Zhong1 paper · Nanjing University of Information Science and Technology

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Ling LiiD· 2 shared Angela JeongiD· 1 shared David Alan BennettiD· 1 shared Jesse W. WilliamsiD· 1 shared Martin O. BergöiD· 1 shared Shaowu ChengiD· 1 shared Yingzheng XuiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 13 mutual co-author links

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2 shared papersNeuroscience

Ling LiORCID

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2 papers

Recent·Most cited

Loss of TREM2 exacerbates parenchymal amyloid pathology but diminishes CAA in Tg-SwDI mice

Rui Zhong, Yingzheng Xu, Jesse W. Williams, Ling Li

This study shows that TREM2 loss increases parenchymal amyloid-beta but reduces cerebral amyloid angiopathy in Tg-SwDI mice.

bioRxiv · Nov 4, 2023 · PreprintNeuroscience

Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice

Angela Jeong, Shaowu Cheng, Rui Zhong, David Alan Bennett, Martin O. Bergö, Ling Li

The paper investigates the role of farnesyltransferase (FT) in Alzheimer's disease by analyzing human brain tissue and generating a mouse model with neuronal FT knockout, finding increased FT and farnesylation in AD and showing mitigation of pathology with FT suppression.

Acta Neuropathologica Communications · Jul 27, 2021Peer-reviewedNeuroscience