Jonathan Rafael‐Patiño

Cortical organoid diffusion MRI reveals protocol-associated spatial reproducibility and increasing apparent diffusivity with diffusion time

This study uses cortical organoids to examine diffusion MRI reproducibility and apparent diffusivity changes with diffusion time, finding increased apparent mean diffusivity in most tissue voxels.

OCTOPUS: A versatile open-source tool creating realistic numericalbrain cells

OCTOPUS generates realistic digital brain cells with complex geometries to improve dMRI signal modeling and validate biophysical models.

CATERPillar: A Flexible Framework for Generating White Matter Numerical Substrates with incorporated Glial Cells

CATERPillar generates realistic white matter numerical substrates with axons and glial cells, validated against histology and diffusion models.

Validating the Standard Model of diffusion MRI in white matter with Numerical Substrates

This study evaluates the Standard Model of diffusion MRI in white matter by testing it on realistic numerical substrates, revealing how model estimates change under various biological conditions and noise levels.

Do you see what I see? Diffusion imaging protocol heterogeneity biases ischemic core volume, location, and clinical associations in acute stroke

This paper shows that differences in diffusion imaging protocols affect ADC maps, leading to variations in infarct core volume, location, and clinical score associations in acute stroke.

Susceptibility-induced internal gradients reveal axon morphology and cause anisotropic effects in the dMRI signal

The paper shows that internal magnetic gradients affect diffusion MRI signals in myelinated axons, revealing morphology-dependent anisotropy previously unseen in 2D models.

Insights from the IronTract challenge: optimal methods for mapping brain pathways from multi-shell diffusion MRI

The paper evaluates tractography methods using a macaque dataset to determine optimal approaches for mapping brain pathways from multi-shell diffusion MRI.

Tractography dissection variability: what happens when 42 groups dissect 14 white matter bundles on the same dataset?

This study evaluates variability in white matter bundle segmentation across 42 groups using the same dataset, finding protocol variability exceeds other sources of inconsistency.

Axon morphology is modulated by the local environment and impacts the non-invasive investigation of its structure-function relationship

The paper shows that axon morphology is influenced by the local environment and affects diffusion MRI estimates of axon diameter and structure-function relationships.

Tractography Reproducibility Challenge with Empirical Data (TraCED): The 2017 ISMRM Diffusion Study Group Challenge

The paper evaluates tractography reproducibility using empirical data from a single healthy volunteer scanned on two scanners, finding high consistency among top algorithms but variability due to tract volume containment.

Limits to anatomical accuracy of diffusion tractography using modern approaches

This study evaluates modern diffusion tractography methods using a standardized challenge, finding no significant improvement in anatomical accuracy despite methodological advances.