Malte Brammerloh

Selective nigrosome vulnerability in Parkinson's disease revealed by histology-anchored ultra-high-field quantitative MRI

This study uses MRI to show that nigrosomes in Parkinson's patients show specific magnetic properties changes, indicating vulnerability without direct neuronal loss.

A precise atlas of the human subcortex

FOCUS, a 100 µm atlas of 180 manually segmented subcortical grey and white matter regions and 77 hand-built tracts, registered to MNI 2009b space for warping to individual brains.

OCTOPUS: A versatile open-source tool creating realistic numericalbrain cells

OCTOPUS generates realistic digital brain cells with complex geometries to improve dMRI signal modeling and validate biophysical models.

Single-cell quantification of the iron-neuromelanin balance in dopaminergic neurons across the lifespan

The paper quantifies iron and neuromelanin in dopaminergic neurons across chimpanzee lifespan, finding stable iron-to-neuromelanin ratios and no evidence of saturation or increased toxicity with age.

Giving you five: A neuroimaging atlas of the nigrosomes in the substantia nigra based on 3D histology

This paper creates a 3D histological atlas of nigrosomes in the substantia nigra aligned to MNI152 space, enabling MRI analysis of these structures in Parkinson's disease.

Multimodal imaging reveals no evidence for magnetite-based magnetoreceptors in the mole-rat eye

The paper uses multimodal imaging to investigate magnetite-based magnetoreceptors in the mole-rat eye and finds no evidence for their presence.

Validating Neurite EXchange Imaging (NEXI) using diffusion Monte Carlo simulations in realistic numerical gray matter substrates

This paper validates the NEXI model using diffusion Monte Carlo simulations in realistic gray matter substrates, showing it accurately recovers exchange times and disentangles exchange effects from microstructural features.

CATERPillar: A Flexible Framework for Generating White Matter Numerical Substrates with incorporated Glial Cells

CATERPillar generates realistic white matter numerical substrates with axons and glial cells, validated against histology and diffusion models.

Toward an early diagnostic marker of Parkinson's: measuring iron in dopaminergic neurons with MR relaxometry

The paper links MRI relaxation rate in substantia nigra to iron concentration in dopaminergic neurons, enabling early Parkinson's disease detection.