Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids
Yasuhiro M. Umemura, Nobuya Koike, Yoshiki Tsuchiya, Hitomi Watanabe, Gen Kondoh, Ryoichiro Kageyama, Kazuhiro Yagita
This study shows that CLOCK/BMAL1 disrupts the segmentation clock in mouse embryonic organoids by interfering with Hes7 oscillation and transcriptional regulation.
Proceedings of the National Academy of Sciences · Dec 20, 2021Peer-reviewedDevelopmental Biology