Ryoichiro Kageyama

This study shows that Plagl2 reprograms adult mouse Müller glia into a progenitor-like state with both proliferative and neurogenic capabilities, enhancing retinal regeneration.

The paper shows that iPaD treatment and Prkag2 knockdown enhance neurogenesis and reduce amyloid-β in Alzheimer's disease model mice by activating AMP kinase signaling.

This study reconstitutes synchronized oscillation in PSM organoids using synthetic cell-cell signaling and identifies the role of ligand-receptor dynamics in synchronization.

This study measures lysosomal protein degradation in neural stem cells of postnatal mouse brain and finds age and disease-related fluctuations in lysosomal activity.

The paper identifies a spinal microcircuit involving V2a and V2b neurons that coordinate ipsilateral body movements during locomotion, showing antagonistic and synergistic roles in motor control.

This study shows that CLOCK/BMAL1 disrupts the segmentation clock in mouse embryonic organoids by interfering with Hes7 oscillation and transcriptional regulation.

This study investigates the role of small extracellular vesicles in regulating neural stem cell quiescence and proliferation, finding that exosome inhibition affects cell cycle entry and maintenance of quiescence.

This study shows Fgf4 is essential for maintaining Hes7 levels and Notch oscillations in the somite segmentation clock, leading to vertebral defects in Fgf4 mutants.

Mouse and human segmentation clocks oscillate at 2-3 h and 5-6 h; slower HES7 degradation and longer delays in human cells, not sequence, explain it.

This study shows Jag1 modulates oscillatory Dll1-Notch-Hes1 signaling in pancreatic progenitors to coordinate their growth and fate, with Jag1 also specifying most bipotent progenitors.

The paper identifies a human segmentation clock by showing human PSM cells exhibit Notch and YAP-dependent oscillations of HES7 with a 5-hour period.