Author

Yasuhiro M. Umemura

Kyoto Prefectural University of MedicineORCID 0000-0003-3202-1124Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Gen KondohiD· 2 shared Hitomi WatanabeiD· 2 shared Kazuhiro YagitaiD· 2 shared Nobuya Koike· 2 shared Akira Sugimoto· 1 shared Akiyo Kakibuchi· 1 shared Kazuya YabumotoiD· 1 shared Ryoichiro KageyamaiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersDevelopmental Biology

Gen KondohORCID

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2 papers

Recent·Most cited

Developmental BiologyPNAS NexusPeer-reviewedAug 24, 2026

11β-HSD2 buffers fetal glucocorticoid exposure inducing Per1 expression under maternal stress

Kazuya Yabumoto, Yasuhiro M. Umemura, Hitomi Watanabe…·Kazuhiro Yagita

This study shows that 11β-HSD2 buffers maternal glucocorticoid surges during early development, preventing premature circadian clock activation and segmentation defects.

DOI 10.1093/pnasnexus/pgag286

mouseexperimental assay

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Developmental BiologyProceedings of the National Academy of SciencesPeer-reviewedDec 20, 2021

Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids

Yasuhiro M. Umemura, Nobuya Koike, Yoshiki Tsuchiya…·Kazuhiro Yagita

This study shows that CLOCK/BMAL1 disrupts the segmentation clock in mouse embryonic organoids by interfering with Hes7 oscillation and transcriptional regulation.

29 citations

mousebulk RNA-seq

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