Author

Gen Kondoh

Kyoto UniversityORCID 0000-0002-2564-0149Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 6 Approach:experimental assay· 5 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Organism:non-human primate· 1 Approach:statistical model· 1

Frequent Co-Authors

Hitomi WatanabeiD· 6 shared Chisa ShukunamiiD· 2 shared Denitsa DochevaiD· 2 shared Kazuhiro YagitaiD· 2 shared Kenta UchibeiD· 2 shared Kotaro TanimotoiD· 2 shared Nobuya Koike· 2 shared Shigenori MiuraiD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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6 shared papersDevelopmental Biology

Hitomi WatanabeORCID

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6 papers

Recent·Most cited

11β-HSD2 buffers fetal glucocorticoid exposure inducing Per1 expression under maternal stress

Kazuya Yabumoto, Yasuhiro M. Umemura, Hitomi Watanabe, Yasuhiro Endo, Nobuya Koike, Akiyo Kakibuchi, Akira Sugimoto, Taisuke Mori, Gen Kondoh, Kazuhiro Yagita

This study shows that 11β-HSD2 buffers maternal glucocorticoid surges during early development, preventing premature circadian clock activation and segmentation defects.

PNAS Nexus · Aug 24, 2026Peer-reviewedDevelopmental Biology

Functional impact of pathogenic Runt domain mutations in Runx2 on skeletal and dental development in cleidocranial dysplasia

Saki Ogawa, Shinnosuke Higuchi, Yuki Yoshimoto, Mari Hoshino, Shigenori Miura, Atsuko Hamada, Hitomi Watanabe, Tetsushi Sakuma, Kadi Hu, Shun Ogata, Kenta Uchibe, Katsumi Fujimoto, Takashi Yamamoto, Tetsuji Okamoto, Ryo Kunimatsu, , Chisa Shukunami

This study investigates the functional impact of pathogenic RHD mutations in Runx2 on skeletal and dental development in a mouse model of cleidocranial dysplasia.

bioRxiv · Jun 18, 2025 · PreprintGenetics

Ca2+-evoked sperm cessation determines embryo number in mammals.

Hitomi Watanabe, Daiya Ohara, Shinichiro Chuma, Yusuke Takeuchi, Tomoatsu Takano, Ami Katanaya, Satohiro Nakao, Akihisa Kaneko, Takatoku Oida, Tatsuya Katsuno, Takuya Uehata, Toru Takeo, Munehiro Okamoto, Keiji Hirota, Gen Kondoh

The paper identifies a Ca2+-dependent sperm subpopulation that regulates embryo number in mammals by reducing fertilization rates when removed.

bioRxiv · Sep 16, 2024 · PreprintDevelopmental Biology

Sclerostin modulates the degree of mineralization and the stiffness profile of the fibrocartilaginous enthesis for mechanical tissue integrity

Shinsei Yambe, Yuki Yoshimoto, Kazutaka Ikeda, Koichiro Maki, Aki Takimoto, Akihide Tokuyama, Shinnosuke Higuchi, Xinyi Yu, Kenta Uchibe, Shigenori Miura, Hitomi Watanabe, Tetsushi Sakuma, Takashi Yamamoto, Kotaro Tanimoto, Gen Kondoh, , Chisa Shukunami

This study investigates how sclerostin modulates mineralization and stiffness in fibrocartilaginous entheses to maintain mechanical integrity.

Frontiers in Cell and Developmental Biology · Jun 4, 2024Peer-reviewedDevelopmental Biology

Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids

Yasuhiro M. Umemura, Nobuya Koike, Yoshiki Tsuchiya, Hitomi Watanabe, Gen Kondoh, Ryoichiro Kageyama, Kazuhiro Yagita

This study shows that CLOCK/BMAL1 disrupts the segmentation clock in mouse embryonic organoids by interfering with Hes7 oscillation and transcriptional regulation.

Proceedings of the National Academy of Sciences · Dec 20, 2021Peer-reviewedDevelopmental Biology

Inhibition of N-myristoyltransferase Promotes Naive Pluripotency in Mouse and Human Pluripotent Stem Cells

Junko Yoshida, Hitomi Watanabe, Kaori Yamauchi, Takumi Nishikubo, Ayako Isotani, Satoshi Ohtsuka, Hitoshi Niwa, Hidenori Akutsu, Akihiro Umezawa, Hirofumi Suemori, Yasuhiro Takashima, Gen Kondoh, Junji Takeda, Kyoji Horie

This study shows that inhibiting N-myristoyltransferase (Nmt) promotes naive pluripotency in both mouse and human pluripotent stem cells.

bioRxiv · Jun 22, 2021 · PreprintDevelopmental Biology