Frank Leypoldt

Neuropathic pain and distinct CASPR2 autoantibody IgG subclasses drive neuronal hyperexcitability

The paper investigates how CASPR2 autoantibody subclasses, particularly IgG4, affect neuronal excitability and potassium channel function in patients with neuropathic pain.

CSF single-cell RNA sequencing reveals clonally expanded CD4+ stem cell-like memory T cells in GAD65-antibody associated neurological syndromes

The paper uses single-cell RNA sequencing to identify clonally expanded CD4+ stem cell-like memory T cells in the CSF of anti-GAD65 AINS patients, suggesting their role in disease pathogenesis.

Persistent cognitive deficits in anti-LGI1 encephalitis are linked to a reorganization of structural brain networks

This study links persistent cognitive deficits in anti-LGI1 encephalitis to structural brain network reorganization despite immunotherapy and clinical recovery.

CSF plasma cell expansion in LGI1-/CASPR2-autoimmune encephalitis is associated with loss of regulatory MAIT cells

The paper uses single-cell transcriptomics to show CSF-specific plasma cell expansion and systemic loss of MAIT cells in anti-LGI1/CASPR2 autoimmune encephalitis.