CSF single-cell RNA sequencing reveals clonally expanded CD4+ stem cell-like memory T cells in GAD65-antibody associated neurological syndromes
Sumanta Barman, Saskia Jania Räuber, Katharina Eisenhut, Daniela Esser, Martijn M. VanDuijn, Madeleine Scharf, Marisol Herrera-Rivero, Paul Disse, Marius Jonas, Duygu Pul, Michael Heming, Louisa Müller‐Miny, Manuela Paunovic, Christine Strippel, Ebru Haholu, , cooperation with the EMC-AIE Study group
The paper uses single-cell RNA sequencing to identify clonally expanded CD4+ stem cell-like memory T cells in the CSF of anti-GAD65 AINS patients, suggesting their role in disease pathogenesis.
bioRxiv · May 18, 2025 · PreprintImmunology