Michael Heming

Morphologic intratumoral heterogeneity from routine whole-slide histopathology is prognostic for survival in primary central nervous system lymphoma: development in the LOC Network and international external validation

The paper develops and validates a prognostic model using morphologic intratumoral heterogeneity from histopathology slides to predict survival in primary central nervous system lymphoma.

The nuclear receptor NR4A1 serves as a neutrophil-intrinsic regulator mitigating stroke severity

This study identifies NR4A1 as a neutrophil-intrinsic regulator that reduces stroke severity by limiting inflammation and brain damage through pharmacological modulation.

Multi-omic characterization of human sural nerves acrosspolyneuropathies

The paper integrates single nuclei transcriptomics and spatial transcriptomics of human peripheral nerves to identify novel cell markers, reveal pan-nerve disease characteristics, and demonstrate potential for unbiased diagnostic classification.

CSF single-cell RNA sequencing reveals clonally expanded CD4+ stem cell-like memory T cells in GAD65-antibody associated neurological syndromes

The paper uses single-cell RNA sequencing to identify clonally expanded CD4+ stem cell-like memory T cells in the CSF of anti-GAD65 AINS patients, suggesting their role in disease pathogenesis.

CSF plasma cell expansion in LGI1-/CASPR2-autoimmune encephalitis is associated with loss of regulatory MAIT cells

The paper uses single-cell transcriptomics to show CSF-specific plasma cell expansion and systemic loss of MAIT cells in anti-LGI1/CASPR2 autoimmune encephalitis.