Gerd Meyer zu Hörste

Morphologic intratumoral heterogeneity from routine whole-slide histopathology is prognostic for survival in primary central nervous system lymphoma: development in the LOC Network and international external validation

The paper develops and validates a prognostic model using morphologic intratumoral heterogeneity from histopathology slides to predict survival in primary central nervous system lymphoma.

Spermatogonial stem cells and their differentiation roadmap throughout marmoset development

This study identifies transcriptional states and regulators of spermatogonial stem cell differentiation in marmoset testes across developmental stages.

The nuclear receptor NR4A1 serves as a neutrophil-intrinsic regulator mitigating stroke severity

This study identifies NR4A1 as a neutrophil-intrinsic regulator that reduces stroke severity by limiting inflammation and brain damage through pharmacological modulation.

Multi-omic characterization of human sural nerves acrosspolyneuropathies

The paper integrates single nuclei transcriptomics and spatial transcriptomics of human peripheral nerves to identify novel cell markers, reveal pan-nerve disease characteristics, and demonstrate potential for unbiased diagnostic classification.

CSF single-cell RNA sequencing reveals clonally expanded CD4+ stem cell-like memory T cells in GAD65-antibody associated neurological syndromes

The paper uses single-cell RNA sequencing to identify clonally expanded CD4+ stem cell-like memory T cells in the CSF of anti-GAD65 AINS patients, suggesting their role in disease pathogenesis.

In vitro spatiotemporal reconstruction of human skeletal muscle organogenesis

This paper introduces a 3D in vitro system to model human skeletal muscle development and identifies a pool of myogenic progenitors that can resist specification and expand in vitro.

CSF plasma cell expansion in LGI1-/CASPR2-autoimmune encephalitis is associated with loss of regulatory MAIT cells

The paper uses single-cell transcriptomics to show CSF-specific plasma cell expansion and systemic loss of MAIT cells in anti-LGI1/CASPR2 autoimmune encephalitis.

EGR4-dependent decrease of UTF1 is associated with failure to reserve spermatogonial stem cells in infertile men

The paper identifies EGR4-dependent UTF1 downregulation as a factor in reduced reserve spermatogonial stem cells in infertile men, linked to altered chromatin structure.