Sox4 in Treg Cells Suppresses IL-10 Production via c-Maf Degradation and Exacerbates Type 2 Inflammation
Yuki Hayashi, Kensuke Suga, Akira Suto, Arifumi Iwata, Junichi Ishikawa, Kazuya Abe, Takahiro Kageyama, Takashi Ito, Shigeru Tanaka, Kotaro Suzuki, Masakatsu Yamashita, Véronique Lefèbvre, Hiroshi Nakajima
This study identifies Sox4 as a suppressor of IL-10 production in Treg cells by degrading c-Maf, leading to exacerbated type 2 inflammation in asthma models.
bioRxiv · Nov 4, 2025 · PreprintImmunology