Author

Lan Xu

Queen Mary University of LondonORCID 0000-0002-8978-9233Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alex de MendozaiD· 4 shared Luke A. SarreiD· 2 shared Pedro Romero CharriaiD· 2 shared Allan M. Carrillo‐BaltodanoiD· 1 shared Arnau Sebé-PedrósiD· 1 shared Beatriz Loria-VinuezaiD· 1 shared Billie E. DaviesiD· 1 shared Cristina NavarreteiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersGenomics

Alex de MendozaORCID

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4 papers

Recent·Most cited

A chimeric infection program and epigenetic conflict underpin endogenous giant virus latency

Uri Sheyn, Richard Heery, María P. Erazo-Garcia, Lan Xu, Rory J. Craig, Alex de Mendoza, Frank O. Aylward

The paper investigates how a giant virus maintains latency in a green alga by analyzing its genomic architecture and epigenetic regulation.

bioRxiv · Oct 10, 2026 · PreprintMicrobiology

Pervasive co-option of prokaryotic adenine methyltransferases by eukaryotic retrotransposons

Manuel Moreno, Pedro Romero Charria, Lan Xu, Beatriz Loria-Vinueza, Manuel Irimia, Ignacio Maeso, Alex de Mendoza

This study identifies eukaryotic retrotransposons that encode prokaryotic-like DNA adenine methyltransferases and shows their adaptation to host 6mA-associated chromatin.

bioRxiv · May 22, 2026 · PreprintGenomics

Adenine DNA methylation associated to transcription is widespread across eukaryotes

Pedro Romero Charria, Cristina Navarrete, Vladimir Y. Ovchinnikov, Lan Xu, Luke A. Sarre, Victoria Shabardina, Ewa Księżopolska, Elena Casacuberta, David Lara‐Astiaso, Arnau Sebé-Pedrós, Alex de Mendoza

The paper profiles 6mA methylation in 18 eukaryotes and finds it is linked to transcription and associated with H3K4me3-enriched nucleosomes, but is lost in major multicellular lineages.

Nature Genetics · Nov 18, 2025Peer-reviewedGenomics

Annelid methylomes reveal ancestral developmental and ageing-associated epigenetic erosion across Bilateria

Kero Guynes, Luke A. Sarre, Allan M. Carrillo‐Baltodano, Billie E. Davies, Lan Xu, Yan Liang, Francisco M. Martín-Zamora, Paul J. Hurd, Alex de Mendoza, José María Martín-Durán

The paper analyzes methylomes in annelids to show ancestral epigenetic erosion during development and aging, with gene body methylation linked to transcription and TE silencing.

Genome biology · Aug 1, 2024Peer-reviewedGenomics