Vladimir Y. Ovchinnikov

This study presents a multi-omic atlas of the siphonophore Physalia utriculus, revealing the regulatory mechanisms of colonial division of labour and the molecular basis of venom activity.

The paper introduces WxS-QC, a quality control pipeline for human WGS and WES data, and provides an open test dataset to evaluate QC methods.

The paper profiles 6mA methylation in 18 eukaryotes and finds it is linked to transcription and associated with H3K4me3-enriched nucleosomes, but is lost in major multicellular lineages.

The paper investigates the evolutionary origins of DNA methylation, finding it was likely acquired from bacterial donors to silence transposable and viral elements across eukaryotes.

The paper shows that placental phenotypes in mammals can be predicted from miRNA repertoires with high accuracy, revealing constrained genetic pathways for convergent evolution.

This study estimates that ~6% of insulin-treated diabetic individuals with ambiguous features in British Pakistanis and Bangladeshis have T1D, highlighting the need for autoantibody and C-peptide testing.

MirGeneDB 3.0 updates the microRNA gene database with expanded species coverage, refined nomenclature, and improved covariance models for phylogenetic analysis.

The paper shows that DNA methylation in Amoebidium appalachense silences endogenized giant viruses, contributing 14% of its genes and revealing a dynamic process of viral integration and purging.

MirGeneDB 2.0 expands curated microRNA gene annotations to 45 metazoan species, revealing many false positives and missing miRNAs in previous annotations.