GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signalling nanodomains
Rebeca Martínez Lázaro, Teresa Minguez, Andrea Reyes-Carrión, Ricardo J. Gómez, Diego Álvarez de la Rosa, David Bartolomé‐Martín, Teresa Giráldez
This study investigates how GRIN2B mutations affect NMDA receptor-BK channel coupling, showing that V618G disrupts complex formation and functional coupling, contributing to EIEE27 pathophysiology.
The Journal of General Physiology · Jul 8, 2025Peer-reviewedPhysiology