Author

Tie-Bo Zeng

Van Andel InstituteORCID 0000-0002-8999-2952Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

Ji LiaoiD· 3 shared Piroska E. SzabóiD· 3 shared Nicholas Pierce· 2 shared Chang YeiD· 1 shared Chuan HeiD· 1 shared Emily Mengshu He· 1 shared Marie AdamsiD· 1 shared Mary F. MajewskiiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersGenetics

Ji LiaoORCID

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4 papers

Recent·Most cited

GeneticsbioRxivPreprintOct 7, 2025

Maternal SETDB1 enables development beyond cleavage stages by extinguishing the MERVL-driven 2-cell totipotency transcriptional program in the mouse embryo

Tie-Bo Zeng, Zhen Fang Fu, Mary F. Majewski…·Piroska E. Szabó

The paper shows that maternal SETDB1 is essential for silencing 2-cell totipotency genes in mouse embryos, allowing development beyond the 8-cell stage.

2 citations

mousebulk RNA-seq

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Molecular BiologybioRxivPreprintMay 11, 2025

Advanced eTAM-seq enables high-fidelity, low-input N6-methyladenosine profiling in human cells and embryonic mouse tissues

Emily Mengshu He, Yuanyuan Wu, Chang Ye…·Weixin Tang

The paper introduces eTAM-seq-v2, an improved method for m6A profiling with higher fidelity and lower input requirements, and applies it to human cells and mouse tissues.

1 citation

humanmouse

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GeneticsEpigenomicsPeer-reviewedAug 1, 2021

H3K9 methyltransferase EHMT2/G9a controls ERVK-driven non-canonical imprinted genes

Tie-Bo Zeng, Nicholas Pierce, Ji Liao, Piroska E. Szabó

The paper shows EHMT2 maintains non-canonical imprinting by repressing ERVK promoters through DNA methylation and H3K4me3.

17 citations

mouseDNA methylation

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Developmental BiologybioRxivPreprintMar 29, 2021

EHMT2 Controls Transcriptional Noise and the Developmental Switch after Gastrulation in the Mouse Embryo

Tie-Bo Zeng, Nicholas Pierce, Ji Liao…·Piroska E. Szabó

The paper investigates the role of EHMT2 in transcriptional regulation during mouse embryonic development, finding it controls transcriptional noise and developmental gene switches.

2 citations

mousebulk RNA-seq

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