Marie Adams

This paper identifies an alternatively spliced NF1 isoform, NLS SE, that promotes luminal breast cancer progression by disrupting nuclear neurofibromin function and reprogramming ER signaling toward post-transcriptional regulation.

The paper analyzes bone marrow microenvironment changes in HMA-resistant MDS patients treated with guadecitabine and atezolizumab, finding that long-term survivors show reduced immunosuppressive monocytes and expanded effector lymphocytes.

This paper shows that a high-fat diet increases endometrial hyperplasia risk by reprogramming stromal fibroblasts to a pro-fibrotic state driven by estrogen.

The paper identifies PD-associated shifts between 5-methylcytosine and 5-hydroxymethylcytosine in human brain tissue, linking them to genes involved in neuroinflammation and neurodevelopment.

The paper shows that maternal SETDB1 is essential for silencing 2-cell totipotency genes in mouse embryos, allowing development beyond the 8-cell stage.

This study identifies YAP signaling as a driver of resistance to MEK and AKT inhibitors in NF1-related MPNSTs using preclinical models and spatial transcriptomics.

This study shows that developmental exposure to dieldrin causes sex-specific DNA modifications in neurodevelopmental pathways, potentially increasing Parkinson's disease risk later in life.

The paper uses spatial transcriptomics to identify specific cortical neurons vulnerable to Lewy pathology in PD and discovers a conserved molecular dysfunction signature in both mice and humans.

This study integrates metabolomics and RNAseq from the same liver samples to show that prior metabolite extraction does not harm RNAseq quality and reveals pyrimidine metabolism as a key pathway in acute viral infection.

This study shows ARID1A maintains repressive H3.3 chromatin through interactions with CHD4 and ZMYND8, suppressing genes involved in cell motility and epithelial-to-mesenchymal transition in endometriotic cells.

This paper develops a high-throughput DNA methylation array and atlas for mice, revealing tissue-specific methylation patterns and their associations with aging, differentiation, and disease.

STORM-seq improves single-cell RNA sequencing by enhancing detection of non-coding transcripts and transcript-level complexity, revealing new cell states in human fallopian tube epithelium.

This study identifies epigenetic differences between cutaneous and plexiform neurofibromas that drive distinct RAS/MKK/P38 signaling and clinical behavior.

The paper compares ribosomal depletion kits for RNAseq library construction, finding differences in ease of use and transcript length impact on library efficiency.