Author

Danish H Sayed

Rutgers, The State University of New JerseyORCID 0000-0002-9012-4458Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 3 Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Maha AbdellatifiD· 4 shared Chandni S. Thakkar· 3 shared Aishwarya Venkatasubramanian· 2 shared Andreas IvessaiD· 2 shared Minzhen He· 2 shared Nazish SayediD· 2 shared Saleena Alikunju· 2 shared Zhi YangiD· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersCell Biology

Maha AbdellatifORCID

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5 papers

Recent·Most cited

Restoring Klf9 Expression with Pressure Overload Leads to Metabolic Maladaptation and Early Onset of Heart Failure

Aishwarya Venkatasubramanian, Chandni S. Thakkar, Z L Yang, Andreas Ivessa, Nazish Sayed, Maha Abdellatif, Danish H Sayed

The paper shows that restoring Klf9 expression during cardiac hypertrophy initially inhibits hypertrophy but leads to early-onset heart failure.

bioRxiv · Jul 24, 2026 · PreprintCell Biology

Restricting Dietary Isoleucine Promotes Foxo3-Dependent Mitochondrial Respiration by Reducing Caloric Intake

Julianne Austin, Minzhen He, Zhi Yang, Dayyan Sayed, Danish H Sayed, Maha Abdellatif

This study shows that restricting dietary isoleucine improves cardiac health by enhancing Foxo3 expression and mitochondrial function through reduced caloric intake.

bioRxiv · Jul 1, 2026 · PreprintMolecular Biology

The Whsc2/NelfA -dependent transcription complex is required for postnatal cardiac development and heart function.

Saleena Alikunju, Chandni S. Thakkar, Aishwarya Venkatasubramanian, Zhi Min Yang, Andreas Ivessa, Danish H Sayed

This study shows that NelfA is essential for postnatal cardiac development and function, as its loss leads to cardiomyopathy and heart failure.

bioRxiv · Oct 24, 2025 · PreprintCell Biology

Constitutive expression of cardiomyocyte Klf9 precipitates metabolic dysfunction and spontaneous heart failure.

Chandni S. Thakkar, Saleena Alikunju, Aishwarya Venkatasubramanium, Zhi Yang, Nazish Sayed, Maha Abdellatif, Danish H Sayed

This study shows that constant Klf9 expression in cardiomyocytes causes metabolic issues and heart failure by disrupting transcriptional and metabolic balance.

bioRxiv · Jan 16, 2025 · PreprintCell Biology

H2A.Z-dependent and -independent recruitment of metabolic enzymes to chromatin required for histone modifications

Su‐Jung Choi, Yong Heui Jeon, Zhi Yang, Minzhen He, Hye‐Won Shin, Jessica M. Pfleger, Danish H Sayed, Sophie Astrof, Maha Abdellatif

The paper identifies H2A.Z-dependent and -independent recruitment of metabolic enzymes to chromatin and shows their role in histone modifications in mouse heart cells.

bioRxiv · Feb 18, 2019 · PreprintMolecular Biology