Author

Xiaohui Chen

Harbin Medical UniversityORCID 0000-0002-9013-842XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

Bin SuniD· 2 shared Manjie ZhangiD· 2 shared Wenjian Li· 2 shared Hao WangiD· 1 shared Hao WangiD· 1 shared Jian MaiD· 1 shared Qian Zhang· 1 shared Yinghao GuoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

Bin SunORCID

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2 papers

Recent·Most cited

Molecular mechanisms of dynamics-mediated effects of pathogenic missense mutations on Menin protein function

Qian Zhang, Yinghao Guo, Hao Wang, Xiaohui Chen, Wenjian Li, Manjie Zhang, Jian Ma, Bin Sun

This study shows that pathogenic missense mutations affect Menin function through dynamic changes and allostery, not just structural destabilization.

The Journal of Physical Chemistry Letters · Mar 5, 2026Peer-reviewedBiophysics

The disordered JM motif in RTKs promotes classical DFGout conformation formation via dynamic effect

Xiaohui Chen, Hao Wang, Wenjian Li, Manjie Zhang, Bin Sun

This study shows that the disordered JM motif in RTKs dynamically influences DFGout conformation formation, promoting classical conformations favorable for inhibitor binding.

bioRxiv · Oct 28, 2025 · PreprintBiophysics