Pavla Brachova

Dysregulation of alternative splicing patterns in the ovaries of reproductively aged mice

This study identifies age-related alternative splicing changes in mouse ovaries, showing increased isoform diversity and functional impacts on mitochondrial genes.

Loss of Cnot6l impairs inosine RNA modifications in mouse oocytes

The paper investigates inosine RNA modifications in oocytes from Cnot6l-/- and Btg4-/- mice, finding depletion of inosine modifications in Cnot6l-/- oocytes, suggesting a novel mRNA clearance mechanism.

Dot1L-dependent H3K79 methylation facilitates histone variant H2A.Z exchange at DNA double strand breaks and is required for high fidelity, homology-directed DNA repair

This study shows that Dot1L-dependent H3K79 methylation is essential for efficient HDR of DNA double strand breaks and genomic stability.

Codon composition in human oocytes reveals age-associated defects in mRNA decay

This study shows that codon composition affects mRNA stability and protein abundance in human oocytes, with age-related changes in these associations impacting oocyte quality.

ADAR1 A-to-I RNA editing alters codon usage

This study identifies that ADAR1-mediated A-to-I RNA editing in mouse oocytes preferentially targets the wobble position of codons, altering codon usage and potentially affecting mRNA stability and translation efficiency.