Nehemiah S. Alvarez

This study identifies age-related alternative splicing changes in mouse ovaries, showing increased isoform diversity and functional impacts on mitochondrial genes.

This study identifies CXCL17 upregulation and macrophage subsets in mouse prostate under steroid hormone imbalance, linking them to foam cell formation and inflammation.

The paper investigates inosine RNA modifications in oocytes from Cnot6l-/- and Btg4-/- mice, finding depletion of inosine modifications in Cnot6l-/- oocytes, suggesting a novel mRNA clearance mechanism.

This study shows that Dot1L-dependent H3K79 methylation is essential for efficient HDR of DNA double strand breaks and genomic stability.

This study shows that codon composition affects mRNA stability and protein abundance in human oocytes, with age-related changes in these associations impacting oocyte quality.

This study shows that DOT1L methyltransferase activity is essential for early murine hematopoiesis, as its loss causes embryonic lethality and genomic instability in hematopoietic progenitors.

The paper identifies differentially expressed transposable element families in mouse stem cell lineages and suggests their potential roles in lineage differentiation.

This study identifies that ADAR1-mediated A-to-I RNA editing in mouse oocytes preferentially targets the wobble position of codons, altering codon usage and potentially affecting mRNA stability and translation efficiency.