Timothy A. Fields

This study compares the protective effects of NAC and Fomepizole against APAP-induced liver and kidney injury in female mice, showing Fomepizole provides broader protection.

This study shows that acetaminophen-induced acute kidney injury occurs through CYP-independent mechanisms, even when hepatic CYP2E1 is deleted, highlighting the need for kidney-specific therapies.

This study tests DFMO, an FDA-approved drug, in a mouse model of ADPKD and finds it reduces kidney cyst growth and improves kidney health.

This study shows that deleting the IFT-A gene Thm1 in ADPKD mouse models has development-specific effects on kidney cysts, inflammation, and cilia length, suggesting environmental factors influence ciliary homeostasis and disease progression.

This study shows that Dot1L-dependent H3K79 methylation is essential for efficient HDR of DNA double strand breaks and genomic stability.